Sara Nogueira

Share on social media
Ignite Session
On site

Sara Nogueira

Merck Life Science KGaA

Abstract: “mRNAs represent versatile tools to address a wide range of conditions, ranging from infectious diseases to cancer. Each RNA drug requires individual manufacturing and encapsulation conditions – both of which play a critical role in the success of the mRNA therapeutic. We have optimized both workflows to generate mRNA of high quality, purity and efficacy which are then complemented by high performing lipid nanoparticles (LNPs) designed using our novel and versatile library of ionizable lipids. To overcome limitations in manufacturing, we developed a novel process with increased flexibility for clinical applications. In contrast to conventional processes, our PCR-process demonstrated high-quality attributes and in vivo performance. Additionally, the process debottlenecks supply chains and offers scalability into commercial phases. Following successful manufacturing, mRNAs have to be packaged into LNPs to protect them from nucleases in the serum and to mediate successful delivery into target cells. Ionizable lipids (IL) have been shown to be the key drivers of LNP efficacy, toxicity and biodistribution and are critical in designing improved mRNA therapies. We’ve developed a versatile library of novel ILs that lead to safe and robust mRNA delivery in mice. These findings highlight the potential of PCR-based mRNA in combination with a novel promising library of IL for the successful design and acceleration of next-generation mRNA therapeutics, for multiple applications”.
Share on social media

Agenda

Wednesday, July 10 | 
15:30
 — 17:27
Ignite Session
Sign up for for the Curious Future Insight Newsletter

Future Insight e.V. is committed to protecting and respecting your privacy, and we’ll only use your personal information to administer your account and to provide the products and services you requested from us. From time to time, we would like to contact you about our products and services, as well as other content that may be of interest to you. If you consent to us contacting you for this purpose, please tick below to say how you would like us to contact you:

You can unsubscribe from these communications at any time. For more information on how to unsubscribe, our privacy practices, and how we are committed to protecting and respecting your privacy, please review our Imprint/Privacy Statement. By clicking submit below, you consent to allow Future Insight e.V. to store and process the personal information submitted above to provide you the content requested.

Cookies

We use cookies so that we can offer you the best possible website experience. This includes cookies which are necessary for the operation of the app and the website, as well as other cookies which are used solely for anonymous statistical purposes, for more comfortable website settings, or for the display of personalized content. You are free to decide in the Cookie Settings which categories you would like to permit. Please note that depending on what you select, the full functionality of the website may no longer be available. You may review and change your choices at any time. Further information can be found in our Privacy Statement.